Crystal structure of human uracil-DNA glycosylase in complex with a protein ... a protein inhibitor: protein mimicry of DNA. Cell. 1995 Sep 8;82(5):701-8.
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The unusual properties of these protein DNA mimics may provide a foundation for the design of targeted inhibitors of DNA-binding proteins. Publication types.
A paradox for the highly specific Ugi inhibition of UDG is how Ugi can successfully mimic DNA backbone interactions for UDG without resulting in significant ...
Feb 10, 2020 · DNA mimicry Ocr protein, a well-studied T7 phage protein that inhibits host restriction enzymes, can also inhibit host transcription through ...
Phage T7 DNA mimic protein Ocr is a potent inhibitor of BREX defence
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Apr 27, 2020 · Here, we report that T7 bacteriophage Ocr, a DNA mimic protein that protects the phage from the defensive action of type I restriction– ...
Dec 4, 2019 · The rational design of compounds that mimic key interactions at the protein–protein interface is another successful strategy for PPI inhibitor ...
Oct 20, 2020 · Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins ...
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Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: Protein mimicry of DNA. Clifford D Mol. Clifford D Mol. Affiliations.
These mimics target a range of proteins and enzymes such as DNA restriction enzymes, DNA repair enzymes, DNA gyrase and nucleosomal and nucleoid-associated ...
May 23, 2014 · Here we describe the potential of small molecule helix mimetics derived from the oxopiperazine scaffold to target protein complexes where one ...